NCS athletes and former NCS athletes were among the top finishers at the 2021 Toyota U.S. Open held at the Greensboro Aquatic Center.
Baylor Nelson of SwimMAC Carolina won the 200 IM and also finished second in the 400 IM and 200 Back. Reid Mikuta, formerly of SwimGSA and now swimming at Auburn University, won the men’s 100 Breast. Sam Stewart of Club Kick Start took second in the men’s 100 Back and Amanda Ray, formerly with New Wave Swimming and now competing for the University of Florida finished third in the women’s 200 Fly. Top eight finishers with North Carolina ties included:
| Name | Club | Event | Place | |
| Yara Hierath | NC State | Women’s | 800 Free | 6 |
| Will Gallant | NC State | Men’s | 800 Free | 4 |
| Madison Kennedy | UN | Women’s | 50 Free | 6 |
| Baylor Nelson | MAC | Men’s | 200IM | 1 |
| Caleb Maldari | MAC | Men’s | 200IM | 5 |
| Baylor Nelson | MAC | Men’s | 400IM | 2 |
| Logan Zucker | MAC | Men’s | 400IM | 6 |
| Grace Rainey | MAC | Women’s | 100 Breast | 5 |
| Reid Mikuta | AUBURN | Men’s | 100 Breast | 1 |
| Sam Stewart | CKS | Men’s | 100 Back | 2 |
| Baylor Nelson | MAC | Men’s | 200 Back | 2 |
| Caleb Maldari | MAC | Men’s | 200 Back | 5 |
| Grace Rainey | MAC | Women’s | 200 Breast | 4 |
| Sofia Plaza | MAC | Women’s | 200 Breast | 6 |
| Matthew Lucky | MAC | Men’s | 200 Breast | 4 |
| Ben Delmar | MAC | Men’s | 200 Breast | 6 |
| Matthew Kroll | MAC | Men’s | 200 Breast | 7 |
| Amanda Ray | FLORIDA | Women’s | 200 Fly | 3 |
| Logan Zucker | MAC | Men’s | 200 Fly | 6 |
| Will Gallant | NC State | Men’s | 1500 Free | 4 |
